Cycfization of the Phosphate Side Chain of Adenosine Triphosphate: Formation of Monoadenosine 5'-Trimetaphosphate

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Science  26 Jul 1974:
Vol. 185, Issue 4148, pp. 352-355
DOI: 10.1126/science.185.4148.352


Monoadenosine 5'-trimetaphosphate has been prepared from adeno-sine 5'-triphosphate by a carbodiimide-mediated condensation. The molecule was characterized by 3lP nuclear magnetic resonance, and its 31P spectrum was simulated through the assumption of a three-phosphorus spin system. The molecule is highly reactive and is rapidly converted to adenosine triphosphate upon contact with water.