Platelet and Plasma Fibrinogens Are Identical Gene Products

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Science  26 Jul 1974:
Vol. 185, Issue 4148, pp. 368-370
DOI: 10.1126/science.185.4148.368


Human platelet fibrinogen has been shown to be indistinguishable from plasma fibrinogen by a variety of criteria, including subunit composition and cross-linking characteristics as judged by sodium dodecyl sulfate-gel electro phoresis, quantitative amino terminal analysis of fibrin, and the amino acid compositions of fibrinopeptides released from platelet and plasma fibrinogens is products of the same gene or genes.