Lysosomal and Microsomal Glucuronidase: Genetic Variant Alters Electrophoretic Mobility of Both Hydrolases

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Science  02 Aug 1974:
Vol. 185, Issue 4149, pp. 442-444
DOI: 10.1126/science.185.4149.442


An electrophoretic variant of β-glucuronidase is present in certain inbred mouse lines. The variant simultaneously affects the mobility of the lysosomal and microsomal forms of the enzyme. The difference is inherited as a single gene mapping at the position of the structural gene on chromosome 5. This confirms that β-glucuronidase at both intracellular sites is coded by the same structural gene.