Reversal of Morphine Tolerance after Medial Thalamic Lesions in the Rat

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Science  02 Aug 1974:
Vol. 185, Issue 4149, pp. 449-451
DOI: 10.1126/science.185.4149.449


Tolerance, manifested by a diminished electroencephalographic response at cortical and subcortical recording sites, was found in rats subjected to repeated systemic injections of morphine sulfate. Reversal of tolerance to morphine resulted from destruction of the medial thalamus.