Reports

Amphetamine Effects in Man: Paradoxical Drowsiness and Lowered Electrical Brain Activity (CNV)

Science  02 Aug 1974:
Vol. 185, Issue 4149, pp. 451-453
DOI: 10.1126/science.185.4149.451

Abstract

Thirteen of 20 normal adults given 10 milligrams of dextroamphetamine exhibited paradoxical drowsiness accompanied by lowered electrical brain activity (contingent negative variation, or CNV) in the first hour post-drug. During this period, seven subjects showed behavioral alertness and increased CNV amplitude. Both groups of subjects showed heightened alertness 2 and 3 hours post-drug. Amphetamine is not a simple stimulant of the central nervous system but can also act as a depressant.

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