Reports

5-Hydroxyindoleacetic Acid in the Lumbar Fluid: A Specific Indicator of Spinal Cord Injury

+ See all authors and affiliations

Science  09 Aug 1974:
Vol. 185, Issue 4150, pp. 527-528
DOI: 10.1126/science.185.4150.527

Abstract

In cats, 19 days after the lower thoracic cord was injllred, the concentrations of 5-hydroxytryptamine and its metabolite 5-hydroxyindoleacetic acid in the lumbosacral cord and that of 5-hydroxyindoleacetic acid in the lumbar fluid decreased. At the same time the concentrations of these substances in the cord above the lesion and that of 5-hydroxyindoleacetic acid in the cisternal fluid was not significantly altered. Since high concentrations of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid are present in the human lumbosacral cord, it appears that the concentration of 5-hydroxyincdoleacetic acid in the lumbar fluid of animals and man reflects the biochemical changes of 5-hydroxytryptamine in the spinal cord.