Genetic Variation in Coumarin Hydroxylase Activity in the Mouse (Mus musculus)

See allHide authors and affiliations

Science  16 Aug 1974:
Vol. 185, Issue 4151, pp. 612-614
DOI: 10.1126/science.185.4151.612


Basal and phenobarbital-induced rates of hepatic metabolism of coumarin to 7-hydroxycoumarin are markedly higher in DBA/2J mice than they are in the AKR/J, C57BL/6J, and C3H/HeJ strains. Intermediate coumarin hydroxylase activity in F1 hybrids of mating between DBA/2J and the other three strains indicates an additive mode of inheritance.