Acetylcholine Noise: Analysis after Chemical Modification of Receptor

See allHide authors and affiliations

Science  13 Sep 1974:
Vol. 185, Issue 4155, pp. 944-946
DOI: 10.1126/science.185.4155.944


The elementary voltage pulses ("shot effects") produced by the action of acetylcholine molecules on the receptor were studied by analyzing the membrane voltage fluctuations ("noise") after acetylcholine application at the frog neuromuscular junction. The amplitude of these pulses was decreased after treatment with a disulfide-bond reducing agent. The shot effect may thus depend on the structure or conformation of the receptor molecule.