MIF-Like Activity in Simian Virus 40-Transformed 3T3 Fibroblast Cultures

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Science  13 Sep 1974:
Vol. 185, Issue 4155, pp. 955-957
DOI: 10.1126/science.185.4155.955


Simian virus 40-transformed fibroblasts (SV3T3), as compared with their untransformed counterparts (3T3), elaborate a macromolecular product that inhibits macrophage migration and causes macrophages to aggregate and lose one type of cell coat material. I'he SV3T3 cells also lack this surface material relative to 3T3 cells. There may be a relationz between migration inhibition factor (MIF), the cell coat, and cell migration.