Puromycin: A Questionable Drug for Studying the Mechanism of Thyroid Calorigenesis in vivo

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Science  20 Sep 1974:
Vol. 185, Issue 4156, pp. 1060-1061
DOI: 10.1126/science.185.4156.1060


Puromycin fails to alter minimal oxygen consumption of rats treated with thyroxine, provided the rectal temperatures of these rats are maintained at 37.8° to 38.1°C. The previously reported puromycin-induced decline in basal metabolic rate of thyroxine-treated rats may have been due to the hypothermia produced by this drug.