Fenfluramine: Amphetamine Congener That Fails to Maintain Drug-Taking Behavior in the Rhesus Monkey

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Science  20 Sep 1974:
Vol. 185, Issue 4156, pp. 1067-1069
DOI: 10.1126/science.185.4156.1067


Fenfluramine, over a dose range from 0.003 to 3 milligrams per kilogram of body weight, failed to maintain self-injection behavior in rhesus monkeys that had initiated and maintained responding for cocaine or methohexital. This absence of a positive reinforcing effect could not be attributed to a slow onset of drug effect or to the use of behaviorally inactive doses. Fenfluramine, because of its distinctive properties, may produce fewer problems of human abuse than do amphetamine-type agents.