Pulmonary Alveolar Hypoxia: Release of Prostaglandins and Other Humoral Mediators

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Science  27 Sep 1974:
Vol. 185, Issue 4157, pp. 1181-1183
DOI: 10.1126/science.185.4157.1181


Hypoxic ventilation of isolated perfused cat lungs caused the frequent appearance in pulmonary perfusates of biologically active substances, which included prostaglandins or prostaglandin-like compounds. In anesthetized cats, inhibition of prostaglandin biosynthesis with infusions of aspirin (more than 50 milligrams per kilogram) reduced the pulmonary vasoconstrictor and bronchoconstrictor responses to hypoxic breathing.