Morphine and Ethanol: Selective Depletion of Regional Brain Calcium

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Science  04 Oct 1974:
Vol. 186, Issue 4158, pp. 63-65
DOI: 10.1126/science.186.4158.63


Administration of morphine or ethanol to rats produces a decrease in regional brain calcium in vivo. This effect is selectively antagonized by the stereospecific narcotic antagonist naloxone. Reserpine and the dopamine-acetaldehyde conjugate salsolinol also produce a depletion of regional brain calcium, but only the salsolinol depletion is antagonized by naloxone. Experiments with naloxone provide evidence for two calcium-sensitive pools in the central nervous system.