Insulin Secretion by Anomers of D-Glucose

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Science  11 Oct 1974:
Vol. 186, Issue 4159, pp. 150-151
DOI: 10.1126/science.186.4159.150


Isolated rat islets were incubated for 5 minutes in the media containing either the α or β anomer of D-glucose (2 milligrams per milliliter). The amounts of secreted insulin and changes of anomers ratio were concomitantly determined. In spite of rapid mutarotation, significantly greater stimulation of insulin secretion was observed by α-D-glucose as compared with β-D-glucose.