Relation between the Major Histocompatibility (B) Locus and Autoimmune Thyroiditis in Obese Chickens

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Science  18 Oct 1974:
Vol. 186, Issue 4160, pp. 274-275
DOI: 10.1126/science.186.4160.274


Obese strain chickens develop circulating autoantibodies to thyroglobulin and lymphocytic infiltration of their thyroids during aging. Two alleles, B1 and B4, are found with high gene frequency at the major histocompatibility (B) locus. Greater pathology and higher antibody titers are observed in B1B1 and B1B4 birds than in their B4B4 siblings.