Neuroblastoma: Drug-Induced Differentiation Increases Proportion of Cytoplasmic RNA That Contains Polyadenylic Acid

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Science  25 Oct 1974:
Vol. 186, Issue 4161, pp. 359-361
DOI: 10.1126/science.186.4161.359


The production of cytoplasmic RNA that contains polyadenylic acid is increased, relative to total cytoplasmic RNA, in a neuroblastoma clone, NBE-(A), after induction of differentiation by 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone, an inhibitor of adenosine 3',5'-monophosphate phosphodiesterase. The amount of RNA that contains polyadenylic acid in cytoplasm may be greater in such differentiated neuroblastoma cells than in proliferating control cells.