Mammalian Hepatic Lectin

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Science  25 Oct 1974:
Vol. 186, Issue 4161, pp. 365-366
DOI: 10.1126/science.186.4161.365


A rabbit hepatic protein that specifically binds asialoglycoproteins is also a lectin that agglutinates untreated human and rabbit erythrocytes and neuraminidase-treated erythrocytes from rat, mouse, and guinea pig. Both binding of asialoglycoproteins and agglutination of erythrocytes appear to involve reaction on the same active sites of the hepatic protein.