Presynaptic Inhibition: Primary Afferent Depolarization in Crayfish Neurons

See allHide authors and affiliations

Science  01 Nov 1974:
Vol. 186, Issue 4162, pp. 451-454
DOI: 10.1126/science.186.4162.451


Inhibition of transmission between tactile sensory neurons and interneurons in the crayfish was investigated by intracellular recording int the presynaptic processes. Inhibition is correlated with a depolarization of the presynaptic process, as in the mammalian spinal cord; the depolarization is accompanied by a conductance increase, and is mediated by interneurons that can be excited by a variety of routes.