Interspecies Conversion of Clostridium botulinum Type C to Clostridium novyi Type A by Bacteriophage

Science  01 Nov 1974:
Vol. 186, Issue 4162, pp. 456-458
DOI: 10.1126/science.186.4162.456


When Clostridium botulinum type C is cured of its prophage it simultaneously ceases to produce toxin. This nontoxigenic culture can then be converted to another toxigenic bacterial species, Clostridium novyi type A or to toxigenic Clostridium botulinum types C or D, by specific bacteriophages. The toxigenicity and type of toxin produced by these cultures depends upon the continued presence of these bacteriophages.