Gamma-Aminobutyric Acid Effects on Pituitary Gonadotropin Secretion

Science  22 Nov 1974:
Vol. 186, Issue 4165, pp. 738-739
DOI: 10.1126/science.186.4165.738


Gamma-aminobutyric acid (GABA) injected into the third ventricle of male rats promotes the release of pituitary luteinizing hormone (LH) but not follicle-stimulating hormone. When GABA was injected directly into the pituitary it was ineffective in promoting LH release. This evidence suggests that GABA may play a role in controlling the discharge of hypothalamic luteinizing hormone releasing factor.