5-Methyltetrahydrofolic Acid as a Mediator in the Formation of Pyridoindoles

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Science  22 Nov 1974:
Vol. 186, Issue 4165, pp. 741-743
DOI: 10.1126/science.186.4165.741


Enzymes from chick and rat tissues catalyze the reaction of N-methyl tryptamine with 5-methyltetrahydrofolic acid to form 2,3,4,9-tetrahydro-2-methyl-1H-pyrido[3,4b] indole. N,N-Dimethyltryptamine was not formed. With tryptamine as substrate the product is 2,3,4,9-tetrahydro-1H-pyrido[3,4b] indole and not N-methyltryptamine. These pyridoindoles were not formed when S-adenosylmethionine was cosubstrare.