Antihistamines Block Radiation-Induced Taste Aversions

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Science  13 Dec 1974:
Vol. 186, Issue 4168, pp. 1044-1045
DOI: 10.1126/science.186.4168.1044


When rats are treated with an antihistamine prior to being given sublethal doses of ionizing radiation, the formation of a conditioned saccharin aversion is completely inhibited. A profound aversion could be conditioned with histamine diphosphate as the aversive stimulus. The increase in histamine production after radiation exposure represents the physiological basis of radiation-induced taste aversions.