Reports

Skin Carcinogenesis: Cholesterol-5 α, 6 α-Epoxide Hydrase Activity in Mouse Skin Irradiated with Ultraviolet Light

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Science  27 Dec 1974:
Vol. 186, Issue 4170, pp. 1216-1217
DOI: 10.1126/science.186.4170.1216

Abstract

Cholesterol-5α,6α-epoxide hydrase activity was 96 percent greater in skin of hairless mice that were receiving suberythemic ultraviolet light irradiation for 15 weeks than in nonirradiated controls. This enzyme system, which metabolizes cholesterol-5α,6α-epoxide (a known carcinogen), appears to be substrateinducible and is apparently responsible for the concomitant reduction of the sterol carcinogen that occurs prior to tumor induction.

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