Collagenase production by lymphokine-activated macrophages

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Science  24 Jan 1975:
Vol. 187, Issue 4173, pp. 261-263
DOI: 10.1126/science.163038


Macrophages incubated with products (lymphokines) secreted by stimulated spleen cells produced collagenase. Active lymphokines were obtained both from mitogen- and antigen-stimulated lymphocytes. These observations suggest that the degradation of collagen in chronic inflammatory lesions may be caused by macrophage collagenase.