Growth, behavior, and brain catecholamines in lead-exposed neonatal rats: a reappraisal

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Science  31 Jan 1975:
Vol. 187, Issue 4174, pp. 359-361
DOI: 10.1126/science.1167426


Daily oral administration of lead to newborn rats has no adverse effect on their body growth. Lead-treated rats were more active than age-matched controls. Endogenous levels of brain dopamine were unchanged, whereas norepinephrine was increased, suggesting a possible relationship between lead exposure during earliest developmental periods, increased motor activity, and brain norepinephrine, and not brain dopamine as previously postulated.