Folate transport by the choroid plexus in vitro

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Science  14 Feb 1975:
Vol. 187, Issue 4176, pp. 540-542
DOI: 10.1126/science.1167256


Reduced folates are transported from blood into cerebrospinal fluid against a concentration gradient. In vitro, folates were transported into and released by isolated rabbit choroid plexuses. The choroid plexus uptake mechanism was specific for folates, energy dependent, and depressed by cold temperatures. In vivo, the choroid plexus may transport folates from blood to cerebrospinal fluid.