Toxicology and pharmacological action of anabaena flos-aquae toxin

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Science  14 Feb 1975:
Vol. 187, Issue 4176, pp. 542-544
DOI: 10.1126/science.803708


Calves, rats, ducks, and goldfish given lethal oral doses of bacteria-free lyophilized cell suspensions of toxic Anabaena flos-aquae died as a result of respiratory arrest. Experiments with selected animals and pharmacological preparations showed that the main effect of the toxin was production of a sustained postsynaptic depolarizing neuromuscular blockade.