Ornithine decarboxylase activity: control by cyclic nucleotides

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Science  21 Feb 1975:
Vol. 187, Issue 4177, pp. 650-652
DOI: 10.1126/science.163486


Both exposure to cold and administration of aminophylline result in rapid increases in cyclic adenosine monophosphate (cyclic AMP) in the adrenal medulla and adrenal cortex. These increases are followed by dramatic increases in ornithine decarboxylase activity is due to new enzyme systhesis. The data suggest that the decarboxylase activity is regulated by an increase in cyclic AMP.