Basal forebrain and hypothalamic connection to frontal and parietal cortex in the Rhesus monkey

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Science  21 Feb 1975:
Vol. 187, Issue 4177, pp. 660-662
DOI: 10.1126/science.1114317


Horseradish peroxidase was injected in different parts of the frontal and parietal cortex in 17 rhesus monkeys. In all cases the enzyme was transported retrogradely to neurons in the substantia innominata and hypothalamus as well as in the thalamus. These new findings demonstrate that these cortical areas receive direct afferent fibers from limbic basal forebrain areas concerned with emotion and motivation.