Intestinal metabolism of phenacetin in the rat: effect of charcoal-broiled beef and rat chow

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Science  28 Feb 1975:
Vol. 187, Issue 4178, pp. 744-746
DOI: 10.1126/science.1114320


The intestinal metabolism of phenacetin in vitro was increased 1100 percent in rats fed charcoal-broiled ground beef in a semisynthetic diet. The intestinal metabolism of phenacetin was increased 200 percent in rats fed a chow diet, as compared to rats fed the semisynthetic diet. The results obtained suggest a need for studies in man to determine whether charcoal-broiled meat and other dietary constituents can stimulate the intestinal metabolism of phenacetin or other drugs and thereby decrease their absorption and bioavailability.