Selection of a variant lymphoma cell deficient in adenylate cyclase

Science  28 Feb 1975:
Vol. 187, Issue 4178, pp. 750-752
DOI: 10.1126/science.163487


Isoproterenol, a stimulator of adenylate cyclase, was used to select a stable variant clone of mouse lymphosarcoma cells deficient in the enzyme. The inability of four different stimulators to activate cyclic adenosine monophosphate synthesis in the variant, in contrast to its wild-type parent, implies that in normal cells one type of adenylate cyclase molecular can respond to different activators.

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