Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with (14C)deoxyglucose

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Science  07 Mar 1975:
Vol. 187, Issue 4179, pp. 850-853
DOI: 10.1126/science.1114332


An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido(3,4-b)indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human tissues has been described.