Cell-mediated immunity to antigens associated with endogenous murine C-type leukemia viruses

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Science  14 Mar 1975:
Vol. 187, Issue 4180, pp. 959-961
DOI: 10.1126/science.167435


Splenic lymphocytes from (BALB/c times A/J) F 1 mice are cytotoxic for BALB/c fibroblasts infected with an endogenous C-type leukemia virus, but are not cytotoxic for uninfected BALB/c fibroblasts. These results indicate that mice do not exhibit cell-mediated immune tolerance to antigens associated with endogenous C-type viruses.