Changes in protein levels in perfusates of freely moving cats: relation to behavioral state

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Science  14 Mar 1975:
Vol. 187, Issue 4180, pp. 963-965
DOI: 10.1126/science.167436


Perfusates from the brains of freely moving cats, obtained by means of a push-pull cannula, contain high concentrations of proteins. The levels vary in a cyclic fashion and are higher during rapid eye movement sleep than during the waking state. The proteins represent a distinctive class of tissue protein and their changing levels appear to reflect an alteration in the protein content of the extracellular space of brain related to behavioral state.