Chromosome-wide event accompanies the expression of recessive mutations in tetraploid cells

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Science  21 Mar 1975:
Vol. 187, Issue 4181, pp. 1091-1093
DOI: 10.1126/science.1167702


Mutants resistant to 6-thioguanine were induced in pseudotetraploid hybrid Chinese hamster cells homozygous wild-type at the locus for hypoxanthine phophoribosyl transferase but heterozygous for the linked marker glucose-6-phosphate dehydrogenase. About half of these mutants had concomitantly lost the wild-type allele for glucose-6-phosphate dehydrogenase, as expected if mutation plus chromosome segregation had occurred.