Insulin-induced augmentation of lymphocyte-mediated cytotoxicity

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Science  28 Mar 1975:
Vol. 187, Issue 4182, pp. 1206-1208
DOI: 10.1126/science.163492


Physiologic concentrations of insulin enhance the ability of cytotoxic lymphocytes to injure target cells. The effect of insulin closely resembles the action of cholinomimetics and guanosine 3',5'-monophosphate upon this system. Since both insulin and cholinomimetics elevate intracellular concentrations of guanosine 3',5'-monophosphate, a common mode of action is suggested.