Prolactin receptors in rat liver: possible induction by prolactin

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Science  04 Apr 1975:
Vol. 188, Issue 4183, pp. 57-59
DOI: 10.1126/science.163493


A prolactin receptor, present in adult female rat liver, can be induced in males by estrogen. Hypophysectomy diminished receptor levels in the female and rendered males unresponsive to estrogen. A renal pituitary implant blunted the decrease in hypophysectomized females and induced the receptor in hyophysectomized males. The increased receptor level in hypophysectomized males with a renal pituitary implant was preceded by a sustained elevation of circulating prolactin. Our observations suggest that prolactin induces its own receptor.