Reports

Insulin receptor: role in the resistance of human obesity to insulin

Science  18 Apr 1975:
Vol. 188, Issue 4185, pp. 264-266
DOI: 10.1126/science.164059

Abstract

Large adipocytes from obese subjects have similar receptor numbers and affinities for insulin as small adipocytes from subjects of normal weight. These results indicate that the insulin insensitivity of large fat cells from obese humans occurs after the insulin-receptor interaction and might be explained by either a dilution of receptors over the cell surface or by alterations in intracellular metabolism.

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