Inhibition of immune responses in vitro by specific antiserums to Ia antigens

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Science  18 Apr 1975:
Vol. 188, Issue 4185, pp. 268-270
DOI: 10.1126/science.1118728


Mouse antiserums prepared against Ia antigens, which are products of I (immune response) region genes of the H-2 complex, can inhibit both primary (immunoglobulin M) and secondary (immunoglobulin G) immune responses in vitro by mouse spleen cultures to heterologous erythrocytes. Antiserums directed specifically at products of either the H-2K or H-2D loci have no effect on this response.