Fetal hemoglobin restriction to a few erythrocytes (F cells) in normal human adults

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Science  25 Apr 1975:
Vol. 188, Issue 4186, pp. 361-363
DOI: 10.1126/science.804182


During adult life, the quantity of fetal hemoglobin (HbF) present in F cells--that is, rare erythrocytes which are reactive with rabbit antiserum to human HbF during microscopic immunodiffusion--is sufficient to account for all of the small quantity (less than 0.7 percent) of HbF normally present in whole blood. Thus, erythrocytes are normally heterogeneous with respect to the presence of HbF.