Reports

Induction of neural differentiation in cultures of amphibian undetermined presumptive epidermis by cyclic AMP derivatives

+ See all authors and affiliations

Science  25 Apr 1975:
Vol. 188, Issue 4186, pp. 366-369
DOI: 10.1126/science.164060

Abstract

Induction of neural differentiation in cultures of undetermined presumptive epidermis from three amphibian species was achieved by the addition of 1 millimolar dibutyryl adenosine 3',5'-monophosphate, 8-bromadenosine 3',5'-monophosphate, or adenosine C',E'-monophosphate together with theophylline. Adenosine 5'-monophosphate, adenosine 2',3'-monophosphate, dibutyryl guanosine 3',5'-monophosphate, and butyrate at 1 millimolar are ineffective. These results suggest that the action of the primary inductor or inductors may be mediated via adenosine 3',5'-monophosphate.

Related Content