Lysergic acid diethylamide: effect on histone acetylation in rabbit brain

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Science  13 Jun 1975:
Vol. 188, Issue 4193, pp. 1122-1123
DOI: 10.1126/science.1215990


Lysergic acid diethylamide increased acetylation of histones in rabbit cerebral hemispheres and midbrain 30 minutes after intravenous administration of the drug at doses of 10 and 100 micrograms per kilogram of body weight. Evidence for the stimulation of acetylation in individual histone bands was obtained after separation by electrophoresis on polyacrylamied gels.