Insulin-unresponsive tissues respond to superactive insulin-like material

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Science  27 Jun 1975:
Vol. 188, Issue 4195, pp. 1317-1319
DOI: 10.1126/science.1170638


Insulin-like material prepared from insulin-Sepharose stimulates glucose oxidation by isolated diaphragm of C57Bl/6J ob/ob mice, but insulin does not. This material is much more effective than insulin on epididymal fat tissue from these mice. Insulin-like material and insulin are equipotent on the corresponding tissues from lean littermates.