Angiotensin II stimulation of prostaglandin production in cultured human vascular endothelium

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Science  18 Jul 1975:
Vol. 189, Issue 4198, pp. 219-220
DOI: 10.1126/science.1138377


Immunoreactive material resembling prostaglandin E accumulates in the medium of cultured human umbilical vein endothelial cells. Prodcution is inhibited by indomethacin and stimulated by angiotensin II. Prostaglandin secretion by endothelium may be important in platelet-dependent thrombotic phenomena, and in local control of vascular permeability and tone in vivo.