Strain differences during intraventricular infusion of norepinephrine: possible role of receptor sensitivity

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Science  25 Jul 1975:
Vol. 189, Issue 4199, pp. 301-303
DOI: 10.1126/science.1145205


Two rat strains previously shown to differ with respect to behavioral activity, regional brain tyrosine hydroxylase activity, and norepinephrine-elicited accumulation of adenosine 3', 5'-monophosphate exhibited differential behavioral responsiveness during the intraventricular infusion of norepinephrine. The results are interpreted in terms of differential catecholamine receptor sensitivity.