Cyclic AMP and cyclic GMP: mediators of the mechanical effects on bone remodeling

Science  08 Aug 1975:
Vol. 189, Issue 4201, pp. 467-469
DOI: 10.1126/science.168639


Compressive forces of physiological magnitude (60 grams per square centimeter) reduce the adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate content of the epiphyses of tibiae from 16-day-old chick embryos. An equivalent hydrostatic pressure applied directly to cells isolated from this tissue also affects cyclic nucleotide accumulation. The tissue response is uniform throughout the epiphysis, whereas the cell response varies according to the area of origin.