Erythrocyte receptors for (Plasmodium knowlesi) malaria: Duffy blood group determinants

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Science  15 Aug 1975:
Vol. 189, Issue 4202, pp. 561-563
DOI: 10.1126/science.1145213


Duffy blood group negative human erythrocytes (FyFy) are resistant to infection by Plasmodium knowlesi, a simian malaria that infects Duffy positive human erythrocytes. The P. knowlesi resistance factor, Duffy negative erythrocytes, occurs in high frequency in West Africa, where the people are resistant to vivax malaria. This suggests that Duffy blood group determinants (Fya or Fyb) may be erythrocyte receptors for P. vivax.