Neuronal locus specificity: trans-repolarization of Xenopus embryonic retina after the time of axial specification

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Science  15 Aug 1975:
Vol. 189, Issue 4202, pp. 563-564
DOI: 10.1126/science.1145214


Signaling within an embryonic Xenopus eye comprised of two fused eye fragments can reprogram, in turn, the anteroposterior and dorsoventral axes of one of the fragments. The responding fragment, subsequently isolated and allowed to round up and innervate the brain, shows corresponding inversions in its retinotectal map. This is the first evidence of trans-repolarization of presumptive retina and provides an assay system for analysis of positional signaling within the retinal field.