Reports

Leukocyte recruitment to airways by cigarette smoke and particle phase in contrast to cytotoxicity of vapor

Science  22 Aug 1975:
Vol. 189, Issue 4203, pp. 634-637
DOI: 10.1126/science.1162344

Abstract

After hamsters had breathed fresh cigarette smoke in a miniature chamber, airways of the lung showed recruitment of polymorphonuclear leukocytes. Exposure to particles alone by removal of the vapor phase with charcoal did not change the leukocyte response. However, exposure to cigarette smoke vapor after removal of particles with Cambridge filters did not recruit leukocytes but produced nuclear and cytoplasmic vacuoles, double nuclei, and exfoliation of cells.

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