Epidermal growth factor: identification of a new hormone in human urine

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Science  05 Sep 1975:
Vol. 189, Issue 4205, pp. 800-802
DOI: 10.1126/science.1172293


Epidermal growth factor is a polypeptide hormone that was previously identified only in mice. It causes proliferation and keratinization of epidermal tissues. An immune affinity column extraction technique was used to purify partially a substance from human urine which was similar to the mouse hormone in both its biological activity and immunoreactivity.